SLU-PP-332

What Is SLU-PP-332?

SLU-PP-332 is a synthetic small-molecule compound originally developed at Saint Louis University, functioning as a potent pan-agonist of estrogen-related receptors (ERRs) — specifically ERRα, ERRβ, and ERRγ. As a member of an emerging class of compounds known as exercise mimetics, SLU-PP-332 is studied for its ability to reproduce cellular and metabolic adaptations associated with aerobic exercise through pharmacological activation of nuclear receptor signaling — without requiring physical exertion.

Estrogen-related receptors are orphan nuclear transcription factors that govern gene networks controlling oxidative metabolism, mitochondrial biogenesis, and energy homeostasis — making SLU-PP-332 one of the most compelling research tools currently available for studying metabolic regulation, mitochondrial health, and exercise-responsive biology.

Supplied by Peptorium at research-grade purity, this lyophilized formulation is intended exclusively for controlled in vitro laboratory research.

How SLU-PP-332 Works

SLU-PP-332 binds to the ligand-binding domain of ERRα with high affinity, triggering interaction with transcriptional coactivators — most notably PGC-1α, the master regulator of mitochondrial biogenesis. This activation initiates a coordinated upregulation of genes involved in:

Fatty acid oxidation — including CD36, fatty acid transport proteins, and key β-oxidation enzymes
Oxidative phosphorylation — upregulating OXPHOS proteins and mitochondrial respiratory chain components
Mitochondrial biogenesis — promoting the formation of new mitochondria in skeletal muscle and cardiac tissue
Glucose transport — upregulating GLUT4 expression, supporting improved glucose metabolism
DDIT4 pathway activation — recapitulating a key genetic response observed following aerobic exercise bouts
This mechanism is distinct from REV-ERB agonists and PPARδ agonists, placing SLU-PP-332 at a unique node in exercise-responsive transcriptional biology.

Research Applications

SLU-PP-332 supplied by Peptorium is utilized in scientific settings to study:

Exercise mimetic research — investigating pharmacological reproduction of aerobic exercise adaptations at the cellular level
Mitochondrial biogenesis — examining PGC-1α-driven mitochondrial formation and function in muscle models
Metabolic syndrome research — studying ERR agonism effects on fat mass, cholesterol, triglycerides, and glucose tolerance
Endurance and performance biology — exploring oxidative fiber transitions and enhanced respiratory capacity in skeletal muscle
Cardiac metabolism research — investigating fatty acid oxidation restoration and mitochondrial reprogramming in cardiac tissue models
Kidney and anti-fibrotic research — examining ERR agonism effects on mitochondrial dysfunction and inflammation in renal tissue
Fat oxidation and body composition — studying lipolytic activity and adipocyte metabolism modulation
Energy homeostasis and aging — exploring ERR signaling in age-related mitochondrial decline and metabolic dysfunction

Why Researchers Choose Peptorium

Peptorium supplies SLU-PP-332 as a research-grade lyophilized compound, formulated for stability, purity, and reproducibility across controlled laboratory protocols. Our compounds are intended for qualified researchers and institutions operating within appropriate legal and ethical research frameworks.

Intended Use

This product is provided solely for in vitro laboratory research use. It is not intended for human or veterinary use of any kind. SLU-PP-332 remains a preclinical research tool with no registered human clinical trials as of 2026.

Legal Disclaimer: This material has not been evaluated by the U.S. Food and Drug Administration (FDA). Nothing on this site is intended to diagnose, treat, cure, or prevent any disease. Use is restricted to qualified researchers or laboratories operating within appropriate legal and ethical research guidelines.

Terms of Sale: All purchases from Peptorium are final. By completing a transaction, the buyer confirms they are a qualified researcher or laboratory professional with the expertise to safely handle research-grade compounds. The purchaser assumes full responsibility for regulatory compliance, proper storage, and appropriate usage.

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